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Cells were recorded with a Plan-Apochromat 63x/1.4 oil objective on a LSM800 Confocal Microscope using the ZEN 2.3 software (all Zeiss)

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Finally, lactylation operates within a dense PTM and metabolic network, complicating attribution of phenotypes to lactylation per se and leaving open whether it is oncogenic or tumor-suppressive in specific contexts [31, 178, 388]